(S,R,S)-MI-1061

SKU: orb3143453

Description

(S,R,S)-MI-1061 is an isomer of MI-1061. It serves as a precursor for synthesizing Antibody-Drug Conjugates (ADCs). MI-1061 acts as a potent, orally bioavailable, and chemically stable inhibitor of MDM2 (MDM2-p53 interaction) with IC50=4.4 nM and Ki=0.16 nM. This compound activates p53 and induces apoptosis in murine SJSA-1 xenograft tissues, exhibiting antitumor properties.

Research Area

Cell Biology

Key Properties

• CAS Number: 1410738-90-7
• MW: 582.45
• Formula: C₃₀H₂₆Cl₂FN₃O₄
• SMILES: O=C1[C@]2(C3(N[C@H](C(NC4=CC=C(C(O)=O)C=C4)=O)[C@H]2C5=C(F)C(Cl)=CC=C5)CCCCC3)C=6C(N1)=CC(Cl)=CC6
• Target: MDM-2/p53,Drug-Linker Conjugates for ADC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MDM-2/p53,Drug-Linker Conjugates for ADC