(S,R,S)-AHPC TFA

SKU: orb1307434

Description

(S,R,S)-AHPC TFA (VHL Ligand 1 TFA) is a VH032-derived compound that recruits the VHL E3 ligase. It serves as a key component in constructing PROTAC degraders, such as those targeting BCR-ABL1, which have demonstrated degradation activity with an IC50 of 1.11 µM in Ba/F3 cell-based assays.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1631137-51-3
• MW: 544.587
• Purity: 97.99% (May vary between batches)
• Formula: C₂₄H₃₁F₃N₄O₅S
• SMILES: CC1=C(C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](N)C(C)(C)C)=O)=O)C=C2)SC=N1.O=C(C(F)(F)F)O
• Target: Ligands for E3 Ligase,PROTAC Linker

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AHPC TFA, (S,R,S)-AHPC, (S,R,S)AHPC TFA, (S,R,S) AHPC TFA, E3 ligase-recruiting Moiety, inhibit, Inhibitor, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, VHL ligand1, VHL ligand-1, VHL ligand 1, VHL ligand 1 TFA, VHL, VH032-NH2, VH032-NH2 TFA

Compound Identifiers

PubChem CID

133053568