(S,R,S)-AHPC TFA

SKU: orb1307434

Description

(S,R,S)-AHPC TFA (VHL Ligand 1 TFA) is a VH032-derived compound that recruits the VHL E3 ligase. It serves as a key component in constructing PROTAC degraders, such as those targeting BCR-ABL1, which have demonstrated degradation activity with an IC50 of 1.11 µM in Ba/F3 cell-based assays.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1631137-51-3
• MW: 544.59
• Purity: 97.99% (May vary between batches)
• Formula: C₂₄H₃₁F₃N₄O₅S
• SMILES: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)N)=O)C[C@H](O)C3.O=C(O)C(F)(F)F
• Target: Ligands for E3 Ligase,PROTAC Linker

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AHPC TFA, (S,R,S)-AHPC, (S,R,S)AHPC TFA, (S,R,S) AHPC TFA, E3 ligase-recruiting Moiety, inhibit, Inhibitor, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, VHL ligand1, VHL ligand-1, VHL ligand 1, VHL ligand 1 TFA, VHL, VH032-NH2, VH032-NH2 TFA

Compound Identifiers

PubChem CID

133053568