(S,R,S)-AHPC-PEG2-NH2 hydrochloride

SKU: orb1307435

Description

This compound is an E3 ligase ligand-linker conjugate, featuring the (S,R,S)-AHPC VHL ligand connected via a two-unit polyethylene glycol (PEG2) linker and an amine terminus. It serves as a key intermediate for constructing PROTAC molecules, which are used in both in vitro and in vivo studies to investigate targeted protein degradation.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2097973-72-1
• MW: 612.18
• Purity: 99.29% (May vary between batches)
• Formula: C₂₈H₄₂ClN₅O₆S
• SMILES: O=C([C@H]1N(C([C@@H](NC(COCCOCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.Cl
• Target: E3 Ligase Ligand-Linker Conjugates,PROTAC Linker
• Solubility: H2O:100 mg/mL (163.35 mM);DMSO:100 mg/mL (163.35 mM)

Bioactivity

• In Vitro:
  PROTACs consist of two ligands joined by a linker: one targets an E3 ubiquitin ligase, and the other targets the desired protein. They harness the intracellular ubiquitin-proteasome system to selectively degrade these target proteins.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AHPC-PEG2-NH2 Hydrochloride, (S,R,S) AHPC PEG2 NH2 hydrochloride, (S,R,S)AHPCPEG2NH2 hydrochloride, (S,R,S)-AHPC-PEG-2-NH2 hydrochloride, E3 Ligase Ligand-Linker Conjugates, E3 Ligase LigandLinker Conjugate, E3 Ligase Ligand-Linker Conjugate, E3 ligase Ligand-Linker Conjugates 6, E3LigaseLigandLinkerConjugate, inhibit, Inhibitor, VHL, VH032-PEG2-NH2 hydrochloride, VH032-PEG2-NH2 Hydrochloride, VHL Ligand-Linker Conjugates 3, VHL Ligand-Linker Conjugates 3 hydrochloride, VHL Ligand-Linker Conjugates 3 Hydrochloride

Compound Identifiers

PubChem CID

131704496