(S,R,S)-AHPC-Boc derivative 1

SKU: orb3028342

Description

(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2086298-33-9
• MW: 560.705
• Formula: C₂₈H₄₀N₄O₆S
• SMILES: C([C@@H](NC(OC(C)(C)C)=O)C(C)(C)C)(=O)N1[C@H](C(N[C@@H](CO)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
• Target: MALT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MALT