SRI 37892

SKU: orb1685249

Description

SRI 37892 is a potent small-molecule inhibitor targeting Frizzled-7 (Fzd7), effectively suppressing canonical Wnt/β-catenin signaling. This activity reduces cancer cell viability, making it a valuable tool for in vitro and in vivo research in oncology, particularly for studying Wnt-driven cancers.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1030769-75-5
• MW: 465.53
• Purity: 99.93% (May vary between batches)
• Formula: C₂₆H₁₉N₅O₂S
• SMILES: C(NC1=NC(=CS1)C=2C=C3C(=CC2)NC(=O)CC3)(=O)C4=CC=C(N5C=6C(N=C5)=CC=CC6)C=C4
• Target: Others,Wnt/beta-catenin
• Solubility: DMSO:50 mg/mL (107.4 mM)

Bioactivity

• In Vitro:
  SRI37892 block Wnt/β-catenin signaling in HEK293 cells induced by Wnt3A and LRP6 with IC50 of 0.66 μM and 0.78 μM, respectively.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FZD7, bcatenin, betacatenin, beta-catenin, Wnt, Wnt/betacatenin, Wnt/b-catenin, Wnt/β-catenin, βcatenin, SRI37892, SRI-37892, SRI 37892

Compound Identifiers

PubChem CID

41550022