SRI-011381 hydrochloride

SKU: orb1302064

Description

SRI-011381 hydrochloride is a novel small molecule agonist of the TGF-β signaling pathway. It is used in research for Alzheimer's disease, showing potential in both in vitro neuronal models and in vivo preclinical studies to modulate neuroprotective pathways.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2070014-88-7
• MW: 365.94
• Purity: 99.59% (May vary between batches)
• Formula: C₂₀H₃₂ClN₃O
• SMILES: Cl.O=C(NC1CCCCC1)N(CC1CCNCC1)Cc1ccccc1
• Target: TGF-beta/Smad
• Solubility: H2O:76.92 mg/mL (210.2 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.47 mM);DMSO:34.29 mg/mL (93.7 mM)

Bioactivity

• In Vivo:
  SRI-011381 protects mice against kainic acid-induced excitotoxicity and neurodegeneration. SRI-011381 (30 mg/kg, dissolved in DMSO) is injected (i.p.) into the SBE-luc mice. SRI-011381 is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%. SRI-011381 by oral gavage of 10, 30, and 75 mg/kg for 14 days resulted in significant changes in hematological endpoints, most notably reductions in red blood cells, hematocrit and hemoglobin. SRI-011381 reduces neurodegeneratio in APP751Lon, Swetransgenic mice.
• In Vitro:
  SRI-11381 is neuroprotective. SRI-011381 promote fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

collagen-1, NALP3, neuroprotective, multiple, inhibit, Inhibitor, sclerosis, Smad, SRI 011381, SRI 011381 hydrochloride, SRI 011381 Hydrochloride, SRI011381, SRI-011381, SRI011381 Hydrochloride, SRI011381 hydrochloride, SRI-011381 Hydrochloride, SRI-011381 hydrochloride [1629138-41-5(free base)], α-SMA, Transforming growth factor beta, TGFbeta/Smad, TGF-beta/Smad, TGFbeta, TGF-beta, TGF-β/Smad, TGF-β, TGFβ, TGFb, TGF-b/Smad

Compound Identifiers

PubChem CID

122198132