Src Inhibitor 1

SKU: orb1304020

Description

Src Inhibitor 1 is a potent, selective dual-site inhibitor of Src tyrosine kinase. It is widely used in cancer research, particularly in studies of tumor cell proliferation and metastasis, and has been applied in both in vitro cellular assays and in vivo animal models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 179248-59-0
• MW: 373.4
• Purity: >99.99% (May vary between batches)
• Formula: C₂₂H₁₉N₃O₃
• SMILES: N(C=1C2=C(C=C(OC)C(OC)=C2)N=CN1)C3=CC=C(OC4=CC=CC=C4)C=C3
• Target: Src
• Solubility: DMSO:3.74 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  Src:44 nM|Lck:88nM
• In Vitro:
  Src-I1 is competitive with both ATP and peptide binding sites of the kinase. The IC50 values are 44 and 88 nM for Src and Lck, respectively. Src-I1, is found to be a potent inhibitor of Src (IC50=0.18 μM), but also inhibited other Src family members, such as Lck, Csk and Yes with similar potency to Src, and RIP2 (IC50=0.026 μM) with even greater potency. In addition, it inhibited CHK2 with similar potency to Src, and Aurora B with slightly lower potency.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Lck, Src, Src-l1, Src Inhibitor 1, Src Inhibitor1, Src Inhibitor-1, Src Kinase Inhibitor 1, Src Kinase Inhibitor1, Src Kinase Inhibitor-1

Compound Identifiers

PubChem CID

1474853