SR-8278

SKU: orb1299461

Description

SR8278 is a potent REV-ERBα antagonist with an EC50 of 0.47 µM, effectively inhibiting receptor activation by agonists like GSK4112. This tool compound is widely used in circadian rhythm, metabolism, and inflammation research, supporting both in vitro mechanistic studies and in vivo pharmacological investigations.

Research Area

Cell Biology

Key Properties

• CAS Number: 1254944-66-5
• MW: 361.49
• Purity: >98%
• Formula: C₁₈H₁₉NO₃S₂
• SMILES: CCOC(=O)C1Cc2ccccc2CN1C(=O)c1ccc(SC)s1
• Target: Transcription factor
• Solubility: Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 35 mg/ml)

Bioactivity

• In Vitro:
  SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SR8278, SR-8278, SR 8278, REV-ERB, REV-ERBα, inhibit, neurosurgery, metabolism, Inhibitor, Alzheimer's disease, biological rhythm, Duchenne muscular dystrophy

Compound Identifiers

PubChem CID

53393127