SR12418

SKU: orb1686834

Description

SR12418 is a synthetic REV-ERBα/β dual ligand that potently suppresses IL-17A production and Th17 cell differentiation. This activity makes it a valuable research tool for investigating autoimmune pathologies, including experimental models of encephalomyelitis and inflammatory bowel disease.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 1801185-08-9
• MW: 483.57
• Purity: 99.96% (May vary between batches)
• Formula: C₃₁H₃₀FNO₃
• SMILES: C(=O)(N1[C@H](COC2=CC=C(OC(C)(C)C)C=C2)CC=3C(C1)=CC=C(F)C3)C=4C5=C(C=CC4)C=CC=C5
• Target: IL Receptor,Autophagy,REV-ERB
• Solubility: DMSO:80 mg/mL (165.44 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (6.82 mM)

Bioactivity

• Target IC50:
  REV-ERBα:68 nM|REV-ERBβ:119 nM
• In Vivo:
  SR12418 (50 mg/kg, intraperitoneal injection, twice daily) can inhibit the onset and disease severity of experimental autoimmune encephalomyelitis (EAE) . Starting from day 18 post-immunization, SR12418 (50 mg/kg, intraperitoneal injection, twice daily) demonstrates therapeutic effects in the intervention study of relapsing-remitting experimental autoimmune encephalomyelitis .
• In Vitro:
  SR12418 at a concentration of 5 μM for 96 hours can inhibit the growth of TH17 cells . Under TH17 polarization induction conditions, SR12418 (5 and 10 μM, 4 days) can suppress cell differentiation .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SR 12418, SR-12418

Compound Identifiers

PubChem CID

91820666