SR12343

SKU: orb3027073

Description

SR12343 is a small molecule inhibitor of the IKK/NF-κB signaling pathway that functions as a NEMO-binding domain (NBD) mimetic. SR12343 inhibits NF-κB activation with an IC50 of 37.02 μM by specifically blocking the critical IKKβ-NEMO interaction, reduces pulmonary inflammation in models, and is suitable for research into inflammatory and degenerative diseases.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2055101-86-3
• MW: 368.66
• Purity: 99.91% (May vary between batches)
• Formula: C₁₅H₁₅BrClN₃O
• SMILES: O=C(NCCC=1C=CC=C(Br)C1)CNC2=NC=C(Cl)C=C2
• Target: NF-κB,IκB/IKK
• Solubility: DMSO:80 mg/mL (217 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SR 12343

Quick Database Links

Gene Symbol

NF-κB,IκB/IKK