SR0987

SKU: orb1302667

Description

SR0987

Research Area

Metabolism Research

Key Properties

• CAS Number: 303126-97-8
• MW: 397.7
• Purity: 99.43%
• Formula: C₁₆H₁₀ClF₆NO₂
• SMILES: OC(c1ccc(NC(=O)c2ccccc2Cl)cc1)(C(F)(F)F)C(F)(F)F
• Target: ROR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.03 mM);DMSO:45 mg/mL (113.15 mM)

Bioactivity

• Target IC50:
  RORγt:800 nM (EC50)
• In Vitro:
  Treatment with SR0987 leads to a significant decrease in the surface expression of PD-1, while desmosterol shows no impact on this parameter. Co-treatment with SR0987 and desmosterol suggests a potential increase in IL17 production. Additionally, SR0987 exhibits a concentration dependent stimulation of Reporter gene expression, achieving an effective concentration (EC50) of approximately 80 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RAR-related orphan receptor, SR 0987, SR0987, SR-0987, ROR, RORγt, LYC-53772, inhibit, Inhibitor

Compound Identifiers

PubChem CID

2323435