SR 57227 hydrochloride

SKU: orb1305641

Description

SR 57227 hydrochloride is a potent, selective, and orally bioavailable 5-HT3 receptor agonist capable of crossing the blood-brain barrier. It exhibits high affinity for 5-HT3 receptors in vitro and has demonstrated antidepressant-like effects in animal models, making it a valuable research tool for neuropsychiatric studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 77145-61-0
• MW: 248.15
• Purity: 99.93%
• Formula: C₁₀H₁₄ClN₃·HCl
• SMILES: Cl.NC1CCN(CC1)c1cccc(Cl)n1
• Target: 5-HT Receptor
• Solubility: DMSO:8.33 mg/mL (33.57 mM)

Bioactivity

• In Vivo:
  Seizure latency was significantly prolonged by a 5-HT3 receptor agonist SR 57227 in a dose-dependent manner. Seizure score and mortality were also decreased by SR 57227 in PTZ-treated mice. Furthermore, these anticonvulsant effects of SR 57227 were inhibited by a 5-HT3 receptor antagonist ondansetron. However, ondansetron alone had no effect on seizure latency, seizure score or mortality at different doses. Immunohistochemical studies have also shown that c-Fos expression was significantly increased in hippocampus (dentate gyrus, CA1, CA3 and CA4) of PTZ-treated mice. Furthermore, c-Fos expression was significantly inhibited by ondansetron in mice treated with PTZ and SR 57227. An ELISA study showed that SR 57227 attenuated the PTZ-induced inhibitory effects of GABA levels in hippocampus and cortex, and the attenuated effects of SR 57227 were antagonized by ondansetron in hippocampus but not cortex. Activation of 5-HT3 receptor by SR 57227, which plays an important role on the control of seizure induced by PTZ, may be related to GABA activity in hippocampus. Therefore, 5-HT3 receptor subtype is a potential target for the treatment of epilepsy.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

immobility, Inhibitor, NG 108-15, inhibit, 5-HT Receptor, 5-HT3, 5-hydroxytryptamine Receptor, 5HTReceptor, 5HT Receptor, blood, brain, anti-depressant, barrier, cell, SR 57227 Hydrochloride, SR 57227 hydrochloride, SR 57227A, SR57227 Hydrochloride, SR-57227 Hydrochloride, Serotonin Receptor

Compound Identifiers

PubChem CID

131746