SR-5037

SKU: orb3210417

Description

SR-5037 is an orally active inhibitor of CDK12 (IC50 = 31 nM) and CDK13, as well as a molecular glue degrader for CycK [DC50 = 30 nM; Dmax > 98%]. It suppresses the enzymatic activity of CDK12/CycK and CDK13/CycK complexes. SR-5037 facilitates the recruitment of DDB1 to the CDK12/CycK complex, triggering proteasome-mediated degradation of CycK. In triple-negative breast cancer mouse models, SR-5037 degrades CycK activity. This compound is potentially useful for cancer research, including triple-negative breast cancer.

Key Properties

• CAS Number: 2387704-74-5
• MW: 535.34
• Formula: C₂₁H₁₈Cl₂F₂N₁₀O
• SMILES: FC(F)N1N=CC(=C1)N2C=NC=3C(=NC(=NC32)N4CCOCC4)NCC5=NC=6C=C(Cl)C(Cl)=CC6N5
• Target: Molecular Glues,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Molecular Glues,CDK