SR-4835

SKU: orb1299034

Description

SR-4835 is a potent and selective dual inhibitor of CDK12 (IC50=99 nM) and CDK13 (Kd=4.9 nM). It has been shown to impair the growth and viability of triple-negative breast cancer (TNBC) cells in vitro, providing a valuable chemical probe for oncology research targeting transcriptional CDKs.

Research Area

Cell Biology

Key Properties

• CAS Number: 2387704-62-1
• MW: 499.36
• Purity: 98.00% (May vary between batches)
• Formula: C₂₁H₂₀Cl₂N₁₀O
• SMILES: Cn1cc(cn1)-n1cnc2c(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)nc(nc12)N1CCOCC1
• Target: Apoptosis,CDK
• Solubility: DMSO:4.8 mg/mL (9.61 mM)

Bioactivity

• Target IC50:
  CDK13:4.9 nM (Kd)|CDK12:99 nM|CDK12:98 nM (Kd)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclin dependent kinase, CDK, Apoptosis, Inhibitor, inhibit, SR4835, SR-4835, SR 4835

Compound Identifiers

PubChem CID

139600338