SR-3306

SKU: orb1706607

Description

SR-3306 is a selective, brain-penetrant pan-JNK inhibitor with IC50 values of 67 nM (JNK1), 283 nM (JNK2), and 159 nM (JNK3). It has been shown to reduce food intake and body weight in vivo, making it a useful research tool for studying metabolic disorders and neurodegenerative diseases.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1128096-91-2
• MW: 490.56
• Purity: 99.81% (May vary between batches)
• Formula: C₂₈H₂₆N₈O
• SMILES: Cc1ccc(cn1)-c1ncn(n1)-c1ccc(Nc2nccc(n2)-c2cccc(c2)N2CCOCC2)cc1
• Target: JNK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.15 mM);DMSO:125 mg/mL (254.81 mM)

Bioactivity

• In Vivo:
  METHODS: Dopaminergic neurons were labeled with antibodies against tyrosine hydroxylase (TH) in brain sections from rats treated with 6-OHDA. Rats received SR-3306 (2.5 mg/kg, 10 mg/kg, subcutaneously, for 14 days). The ability of SR-3306 to prevent nigrostriatal neuronal loss was examined in the 6-OHDA model. RESULTS 6-OHDA-lesioned rats treated with 2.5 mg/kg SR-3306 showed a slight increase in ipsilateral TH-positive neurons, and 10 mg/kg SR-3306 had a significant protective effect against 6-OHDA-induced neurodegeneration when the contralateral side was compared with the ipsilateral side. METHODS: Wild-type lean mice were given SR3306 (30, 60 mg/kg, intraperitoneal injection) to study the effects of SR3306 on food intake and energy balance. RESULTS 30 mg/kg of SR3306 did not affect saccharin intake preference, while a dose of 60 mg/kg produced a strong avoidance response to saccharin.
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• In Vitro:
  METHODS: SR-3306 (0.001-100 μM) was used to treat cisplatin-resistant ovarian cancer cells to study its anticancer activity. RESULTS SR-3306 had inhibitory activity against cisplatin-resistant ovarian cancer cells, with an IC50 value of 0.05 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JNK, inhibit, Inhibitor, SR 3306, SR3306, SR-3306

Compound Identifiers

PubChem CID

57519510