SR-2890

SKU: orb3029074

Description

SR-2890 is a potent and highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with an IC50 of 4 nM for CK1δ. This compound inhibits melanoma A375 cell growth with an EC50 of 38 nM in MTT assays and possesses pharmacokinetic properties suitable for xenograft studies using human cancer cell lines.

Research Area

Metabolism Research, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1454584-91-8
• MW: 477.93
• Purity: 99.10% (May vary between batches)
• Formula: C₂₃H₂₁ClFN₉
• SMILES: FC1=CC=CC(=C1)N2C=NC=3C(=NC(=NC32)N4CCNCC4)NCC5=NC=6C=CC(Cl)=CC6N5
• Target: Casein Kinase

Bioactivity

• In Vivo:
  SR-2890 (1 mg/kg, intravenous administration) was used to treat mice bearing human brain tumor xenograft models to investigate its pharmacodynamics and pharmacokinetics. Results: SR-2890 had a half-life of 1.5 hours in mice and was suitable for xenograft studies of human cancers.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SR2890

Quick Database Links

Gene Symbol

Casein Kinase