Squalene

SKU: orb1221525

Description

Squalene is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil though there are botanical sources as well including rice bran wheat germ and olives. All higher organisms produce squalene including humans. Squalene is an intermediate product in the synthesis of cholesterol and shows several pharmacological properties such as hypolipidemic hepatoprotective cardioprotective antioxidant and antitoxicant activity.

Key Properties

• CAS Number: 111-02-4
• MW: 410.72
• Purity: >98% (HPLC)
• Formula: C₃₀H₅₀
• SMILES: C\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C=C(/C)CC\C=C(/C)CC\C=C(\C)C
• Target: Endogenous Metabolite
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  Animal model: Male mouse models (wild-type, Apoa1-and Apoe-deficient). Dosage: 0.25 g/kg, 1 g/kg. Administration: Fed chow; diets for 11 weeks. Result: Increased high density lipoprotein-cholesterol and paraoxonase 1 and decreases oxidative stress in mice.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AddaVax | all-trans-Squalene | Nikko Squalane EX | trans-Squalene | Super Squalene | Spinacene

Quick Database Links

Gene Symbol

Endogenous Metabolite