SQA1

SKU: orb2564547

Description

SQA1 is a phthalamide-derived small molecule that functions as a dual CCR6 antagonist (Kd 250 nM) and CXCR2 inhibitor. It stabilizes the closed conformation of an intracellular allosteric pocket overlapping the G-protein binding site, making it a valuable tool for investigating chemokine receptor signaling in inflammatory and autoimmune disease models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1255915-27-5
• MW: 426.47
• Formula: C₂₂H₂₆N₄O₅
• SMILES: N(C1=C(N[C@H](CC)C2=CC(C(C)C)=CO2)C(=O)C1=O)C=3C(O)=C(C(N(C)C)=O)N=CC3
• Target: CXCR,CCR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

153466996