SQ22536

SKU: orb1306224

Description

SQ22536

Research Area

Neuroscience

Key Properties

• CAS Number: 17318-31-9
• MW: 205.22
• Purity: 99.18%
• Formula: C₉H₁₁N₅O
• SMILES: Nc1ncnc2n(cnc12)C1CCCO1
• Target: AChR
• Solubility: DMSO:10.3 mg/mL (50.19 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.75 mM)

Bioactivity

• In Vivo:
  SQ22536 abolishes the renal protective effects of liraglutide in KK/Ta-Akita mice. the amelioration of glomerular histopathological damage by liraglutide is eliminated in KK/Ta-Akita mice treated with liraglutide in combination with SQ22536. Renal cAMP does not increase after treatment with SQ22536. In a word, the beneficial actions of liraglutide for treatment of nephropathy are inhibited by the adenylate cyclase inhibitor SQ22536.
• In Vitro:
  SQ22536(250 μMol/L) attenuates the inhibitory effect of adenosine against ADP-induced platelet aggregation from 8±5 to 57±5%, respectively (p<0.001). SQ22536 also attenuates an increase of intraplatelet levels of cAMP by adenosine from 29±2 to 9±1 pmol/108 platelets (p<0.05). It has no effect on the platelet antiaggregant activity of inosine (1 to 4 mmol/L) and ADP-induced platelet aggregation.
• Cell Research:
  HMC-1 cells and hCBMCs are plated in 48-well plates and serum-starved overnight. The next day, cells are preincubated with SQ22536 at the indicated concentrations for 30 min before stimulation with CRH (100 nM for HMC-1 or 1 μM for hCBMC) for 3 min in the presence or absence of SQ22536 in serum-free culture media. Cell lysates are then prepared and assayed for protein kinase A activity using ELISA.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Adenylyl cyclase, adenylate cyclase, Adenylate Cyclase, 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine, SQ 22536, SQ22536, SQ-22536

Compound Identifiers

PubChem CID

5270