SPT-IN-2

SKU: orb3210342

Description

SPT-IN-2 is an orally bioavailable inhibitor of serine palmitoyltransferase (SPT), demonstrating an IC50 of 0.71 nM against human SPT2. This compound suppresses ceramide synthesis and cancer cell proliferation, while exhibiting anti-tumor efficacy, metabolic stability, and cell membrane permeability in xenograft mouse models. SPT-IN-2 efficiently blocks the de novo sphingolipid synthesis pathway, significantly reducing intracellular ceramide and 3-ketodihydrosphingosine (3-KDS) levels. It is applicable in research related to lung adenocarcinoma, acute promyelocytic leukemia, and breast cancer.

Key Properties

• CAS Number: 2035011-97-1
• MW: 542.94
• Formula: C₂₆H₂₂ClF₃N₆O₂
• SMILES: N(C(=O)C1=CC(C(F)(F)F)=NN1C)[C@H]2[C@H](CN(C(=O)C3=CC4=C(C(Cl)=C3)N=CC=N4)CC2)C5=CC=CC=C5
• Target: Acyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Acyltransferase