SPOP-IN-6b

SKU: orb1307731

Description

SPOP-IN-6b is a potent small molecule inhibitor of the SPOP protein, exhibiting an IC50 of 3.58 μM. It serves as a valuable research tool for investigating SPOP's role in renal cell carcinoma, facilitating both in vitro biochemical and cellular studies.

Research Area

Cancer Biology, Protein Biochemistry

Key Properties

• CAS Number: 2136270-20-5
• MW: 500.59
• Purity: 99.93% (May vary between batches)
• Formula: C₂₈H₃₂N₆O₃
• SMILES: Cc1cccn2c1nc1n(CCc3ccccc3)c(=N)c(cc1c2=O)C(=O)NCCCN1CCOCC1
• Target: E1/E2/E3 Enzyme,Others
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  In nude mice, SPOP-IN-6b (40-80 mg/kg; i.p.) slows down the tumour growth.
• In Vitro:
  SPOP-IN-6b (0.1-3.0 μM) inhibits the activity of SPOP, and then increases the content of tumor suppressor substrate proteins PTEN and DUSP7. SPOP-IN-6b. The IC50s are 2-10.2 μM for A498, Caki-2, Ketr-3, 769-P, 0S-RC-2 and 786-0 cells.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2-Imino-10-methyl-N-(3-morpholinopropyl)-5-oxo-1-phenethyl-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide, SPOP, SPOP-IN-6b

Compound Identifiers

PubChem CID

127244279