sPLA2-IIA Inhibitor

SKU: orb1943649

Description

This cyclic pentapeptide analog, c2 (cyclic 2-Nal-Leu-Ser-2-Nal-Arg), is a specific inhibitor of human group IIA secreted phospholipase A2 (sPLA2-IIA). It blocks the enzyme's hydrolysis of the sn-2 ester bond in phospholipids, thereby inhibiting the release of pro-inflammatory mediators like arachidonic acid, making it a valuable tool for studying sPLA2-IIA in inflammatory and cardiovascular disease research models.

Research Area

Metabolism Research; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 236394-37-9
• MW: 750.89
• Formula: C₄₁H₅₀N₈O₆
• SMILES: C(C1=CC2=C(C=C1)C=CC=C2)[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC4=CC5=C(C=C4)C=CC=C5)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC3=O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171361108