Spiraeoside

SKU: orb2663553

Description

Spiraeoside (Quercetin 4′-O-glucoside), a flavonoid from red onion skins, demonstrates antioxidant and cytoprotective activities. It activates the PI3K/Akt/Nrf2 pathway to protect cardiomyocytes from high-glucose injury in vitro and suppresses mast cell activation by inhibiting PLC-γ signaling, relevant for allergy and inflammation research.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 20229-56-5
• MW: 464.38
• Formula: C₂₁H₂₀O₁₂
• SMILES: OC[C@H]1O[C@@H](Oc2ccc(cc2O)-c2oc3cc(O)cc(O)c3c(=O)c2O)[C@H](O)[C@@H](O)[C@@H]1O
• Target: Others
• Solubility: Ethanol:10 mg/mL (21.53 mM);DMSO:10 mg/mL (21.53 mM)

Bioactivity

• In Vivo:
  Spiraeoside (200 mg/kg orally) improved sperm count, motility and testicular morphology in rats.
• In Vitro:
  Spiraeoside attenuated the high glucose (HG) -induced decline in cell viability and increased levels of the myocardial enzymes lactate dehydrogenase and aspartate aminotransferase in AC16 cells. Spiraeoside protects AC16 cells from HG-induced oxidative stress, cell damage and apoptosis. The protective effect of Spiraeoside is regulated by the PI3K/Akt/Nrf2 signaling pathway. Spiraeoside inhibits IGE-mediated mast cell activation and anaphylaxis by inhibiting PLC-γ2/MAPK signaling in Lyn induced mast cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Spiraeoside, Quercetin 4′-O-glucoside

Compound Identifiers

PubChem CID

5320844