α-Spinasterol

SKU: orb1297466

Description

α-Spinasterol

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 481-18-5
• MW: 412.69
• Purity: 99.58%
• Formula: C₂₉H₄₈O
• SMILES: [H][C@@]12CC[C@H]([C@H](C)\C=C\[C@@H](CC)C(C)C)[C@@]1(C)CC[C@@]1([H])C2=CC[C@@]2([H])C[C@@H](O)CC[C@]12C
• Target: COX,TRP/TRPV Channel,Antibacterial
• Solubility: H2O:insoluble;DMSO:insoluble

Bioactivity

• Target IC50:
  COX-2:7.76 μM (IC50)|COX-1:16.17 μM (IC50)
• In Vivo:
  Oral administration of α-spinasterol reduced postoperative pain, when given as a pre- (0.5 h before incision) or post-treatment (0.5 h after incision), and reduced cell infiltration in the injured tissue. α-Spinasterol also reduced the mechanical allodynia induced by partial sciatic nerve ligation and the mechanical and cold allodynia induced by paclitaxel. Moreover, α-spinasterol inhibited COX-1 and COX-2 enzyme activities without altering the body temperature of animals. Importantly, α-spinasterol did not alter spontaneous or forced locomotor activity. Furthermore, it did not cause gastric damage or liver and kidney changes, nor did it alter cell viability in the cerebral cortex and spinal cord slices of mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

COX-2, COX-1, Cyclooxygenase, COX, alpha-Spinasterol, Bacterial, a-Spinasterol, inhibit, Inhibitor, HMG-CoA reductase, TRP Channel, TRPChannel, TRPV Channel, TRPVChannel, TRPV1, Transient receptor potential channels, αSpinasterol, α-Spinasterol, α Spinasterol

Compound Identifiers

PubChem CID

5281331