Spautin-1 (b)

SKU: orb1226644

Description

Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7 uM, but not USP14; promotes cell death under starvation condition and inhibits autophagic cell death, selectively promotes the degradation of Vps34 complexes, reduces the levels of PtdIns3P in cells, but is not a direct inhibitor of class III PI3 kinase activity; promotes the degradation of p53 via inhibition of USP10, which can be inhibited in the presence of MG132; sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib).

Key Properties

• CAS Number: 1262888-28-7
• MW: 271.271
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₁F₂N₃
• SMILES: FC1=CC=C(CNC2=C3C=C(F)C=CC3=NC=N2)C=C1
• Target: DUB
• Solubility: DMSO: 27.1 mg/mL (100 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Spautin1

Quick Database Links

Gene Symbol

DUB