Spastazoline

SKU: orb1298867

Description

Spastazoline is a potent and selective small molecule inhibitor of human spastin, exhibiting an IC50 of 99 nM. This compound is a valuable research tool for studying microtubule dynamics and has been utilized in cellular models to investigate the role of spastin in hereditary spastic paraplegia.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 2351882-11-4
• MW: 382.5
• Purity: >98%
• Formula: C₂₀H₃₀N₈
• SMILES: CC(C)[C@@H]1CN(CCN1)c1nc(Nc2cc([nH]n2)C(C)(C)C)c2cc[nH]c2n1
• Target: Cytoskeleton
• Solubility: Soluble in DMSO (up to 25 mg/ml).

Bioactivity

• Target IC50:
  Sspastn (human):99 nM

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

vesicle transport, Spastazoline, spastin, selective, HeLa, inhibit, Inhibitor, microtubule-severing, division, cell division, AAA protein

Compound Identifiers

PubChem CID

135397891