SP4e

SKU: orb1943643

Description

SP4e is a PPAR-γ activator exhibiting an EC50 of 826.7 nM in HK-2 cell assays. In vivo studies using a Swiss albino mouse model demonstrate its efficacy in improving glycemic control and lipid profiles by reducing blood glucose, total cholesterol, triglycerides, and LDL while elevating HDL levels. This compound is a useful research tool for metabolic disease investigations.

Research Area

Metabolism Research, Molecular Biology

Key Properties

• MW: 440.97
• Formula: C₂₂H₁₇ClN₂O₂S₂
• SMILES: ClC1=CC=CC=C1NC2=CC=C(/C=C3C(N(CC4=CC=C(C)C=C4)C(S/3)=O)=O)S2
• Target: PPAR

Bioactivity

• Target IC50:
  HEK2 cells:826.7 (EC₅₀)
• In Vivo:
  In STZ-induced diabetic mice, SP4e was administered orally at a dose of 10 mg/kg once daily for 15 days. SP4e significantly reduced blood glucose levels, with efficacy comparable to the reference drug pioglitazone (36 mg/kg). SP4e also improved lipid profiles by lowering total cholesterol, triglycerides, and LDL levels while increasing HDL levels. In STZ-induced diabetic zebrafish, SP4e was administered at 10 mg/kg for 10 days. SP4e significantly reduced blood glucose and lipid peroxidation levels, while enhancing antioxidant parameters such as glutathione (GSH) content and catalase (CAT) activity.
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• In Vitro:
  In HEK-2 cells, SP4e activated PPAR-γ with an EC₅₀ of 826.7.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176418796