SP-96

SKU: orb1303133

Description

SP-96 is a potent and selective Aurora B kinase inhibitor (IC50=0.316 nM). It demonstrates selective anti-proliferative activity in cell lines such as MDA-MB-468 and is a useful research tool for studying triple-negative breast cancer in vitro.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 2682114-54-9
• MW: 453.47
• Purity: 99.54% (May vary between batches)
• Formula: C₂₅H₂₀FN₇O
• SMILES: Cn1cc(cn1)-c1ccc2c(Nc3cccc(NC(=O)Nc4cccc(F)c4)c3)ncnc2c1
• Target: Aurora Kinase
• Solubility: DMSO:95 mg/mL (209.5 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (7.28 mM)

Bioactivity

• Target IC50:
  Aurora B:0.316 nM|Aurora A:18.975 nM
• In Vitro:
  SP-96 (63.2 nM) inhibits Aurora B activity in H460 cells by the characteristics of increased DNA content, and it increases cell volume with enormous nucleus. SP-96 shows >2000 fold selectivity against FLT3 (IC50=1475.6 nM) and KIT (IC50=1307.6 nM). SP-96 (0-2 µM) inhibits Aurora A with IC50 value of 18.975 nM. SP-96 (0-1 µM; 24 hours) is not promiscuous, rather selective for a few cell lines, it inhibits MDA-MB-468, CCRF-CEM, COLO 205 and A498 cell growth with GI50 values of 107 nM,47.4 nM, 50.3 nM and 53.2 nM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aurora B, Aurora Kinase, AuroraKinase, Breast Cancer, NCI60, inhibit, hematopoiesis, Inhibitor, Triple Negative, SP96, SP-96, SP 96

Compound Identifiers

PubChem CID

154573766