SP-13786

SKU: orb1299410

Description

SP-13786 is a potent dual inhibitor of fibroblast activation protein (FAP; IC50 = 3.2 nM) and prolyl oligopeptidase (PREP; IC50 = 1.8 µM). This small molecule is a valuable research tool for investigating the roles of these enzymes in fibrosis, cancer, and neurological disorders in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 1448440-52-5
• MW: 344.32
• Purity: 99.96% (May vary between batches)
• Formula: C₁₇H₁₄F₂N₄O₂
• SMILES: C(NCC(=O)N1[C@H](C#N)CC(F)(F)C1)(=O)C=2C3=C(N=CC2)C=CC=C3
• Target: Others,Prolyl Endopeptidase (PREP),Immunology/Inflammation related
• Solubility: DMSO:250 mg/mL (726.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.62 mM)

Bioactivity

• Target IC50:
  PREP:1.8 μM|FAP:3.2 nM
• In Vivo:
  METHODS: SP-13786 (UAMC-1110) (20 mg/kg, orally, twice a day) was used to treat Panc02-SIY cell tumor xenograft mice, and its effect on tumors in the mice was observed. RESULTS Tumor-infiltrating macrophages were reduced during UAMC-1110 administration, and UAMC-1110 significantly increased tumor-infiltrating CD8 T cells, including effector subsets.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FAP, SP 13786, SP13786, SP-13786, UAMC1110, UAMC-1110, UAMC 1110

Compound Identifiers

PubChem CID

71621488