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Sotrastaurin

SKU: orb1225072

Description

A potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes; displays excellent selectivity against a broad panel of kinases (only GSK-3β IC50<1 uM); inhibits early T-cell activation with no general antiproliferative activity, also inhibits β2-integrin-mediated T-cell adhesiveness; prolongs rat heterotopic heart transplant survival in combination with adjunct immunosuppression agents.Blood Cancer Phase 2 Clinical.

Images & Validation

Key Properties

CAS Number425637-18-9
MW438.4812
Purity>98% (HPLC)
FormulaC25H22N6O2
SMILESO=C(C(C1=CNC2=C1C=CC=C2)=C3C4=C5C=CC=CC5=NC(N6CCN(C)CC6)=N4)NC3=O
TargetPKC
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AEB071 | AEB 071 | AEB-071

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Sotrastaurin (orb1225072)

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Available Sizes

Select a size below

5 mg
$ 160.00
10 mg
$ 250.00
25 mg
$ 450.00
50 mg
$ 780.00
100 mg
$ 1,090.00
500 mg
$ 2,150.00