SOS1-IN-21

SKU: orb3136657

Description

SOS1-IN-21 is an orally active inhibitor of son of Sevenless 1 (SOS1) with an IC50 value of 15 nM. As a guanine nucleotide exchange factor (GEF), SOS1 activates KRAS by facilitating the conversion of GDP to GTP. SOS1-IN-21 demonstrates potent antiproliferative activity, with IC50 values of 16 nM for NCI-H358 cells and 17 nM for Mia Paca-2 cells. It exhibits significant antitumor activity in Mia Paca-2 xenograft models and is useful for researching KRAS-mutated tumors, such as pancreatic cancer.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2767633-04-3
• MW: 493.52
• Formula: C₂₅H₃₀F₃N₃O₄
• SMILES: N([C@H](C)C1=C(F)C(C(C(C)(C)O)(F)F)=CC=C1)C=2C3=C(C=C(OC)C(OCCOC)=C3)N=C(C)N2
• Target: Raf

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Raf