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SOS1-IN-18

SKU: orb2944542

Description

SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.

Images & Validation

Key Properties

MW486.53
FormulaC26H29F3N4O2
TargetRas,ERK

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Protocol Information

SOS1-IN-18 (orb2944542)

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