SOS1-IN-15

SKU: orb1744387

Description

SOS1-IN-15 is a potent and orally bioavailable SOS1 inhibitor investigated for its antitumor potential. It is utilized in cancer research, particularly in colon cancer studies, to disrupt the KRAS signaling pathway in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2793404-47-2
• MW: 536.548
• Purity: 98.32% (May vary between batches)
• Formula: C₂₈H₂₇F₃N₆O₂
• SMILES: C(=O)(C1(C#N)CC1)N2C[C@]3(N(CC2)C=4C(OC3)=CC=5C(C4)=C(N[C@H](C)C6=C(F)C(C(F)F)=CC=C6)N=C(C)N5)[H]
• Target: Ras,Raf
• Solubility: DMSO:2 mg/mL (3.73 mM)

Bioactivity

• Target IC50:
  KRAS-SOS1:5 nM
• In Vivo:
  In BALB/c nude mice bearing Mia-paca-2 pancreatic tumors, SOS1-IN-15 (50 mg/kg; oral administration, daily for 22 days) showed 49% tumor inhibition. No animal mortality and significant difference in the mice’s body weight were observed during the study period.
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• In Vitro:
  In Mia-paca-2 pancreatic cancer cells, SOS1-IN-15 (0.1 nM-0.1 mM; 72 hours) inhibited cell proliferation with an IC50 of 178 ± 42 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SOS1

Compound Identifiers

PubChem CID

165437863