Sorafenib N-oxide

SKU: orb1693535

Description

Sorafenib N-oxide, an active metabolite of sorafenib, is a potent and selective inhibitor of FLT3-ITD mutant kinase, showing efficacy in cellular models of acute myeloid leukemia (AML). It also acts as a linear-mixed inhibitor of CYP3A4. This compound is a valuable research tool for studying targeted therapies in FLT3-ITD-driven AML and investigating drug-drug interaction potentials.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 583840-03-3
• MW: 480.83
• Formula: C₂₁H₁₆ClF₃N₄O₄
• SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1=O
• Target: Drug Metabolite,Cytochromes P450,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

9826472