Solithromycin

SKU: orb1305671

Description

Solithromycin is a novel, orally bioavailable macrolide antibiotic that potently inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It demonstrates in vitro efficacy against key respiratory pathogens like Streptococcus pneumoniae and Haemophilus influenzae and has been investigated in clinical trials for community-acquired bacterial pneumonia.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 760981-83-7
• MW: 845.01
• Purity: 98.58%
• Formula: C₄₃H₆₅FN₆O₁₀
• SMILES: CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(nn3)-c3cccc(N)c3)C(=O)O[C@]12C)OC
• Target: Antibiotic,Antibacterial
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.37 mM);DMSO:50 mg/mL (59.17 mM)

Bioactivity

• Target IC50:
  Haemophilus influenzae:125 ng mL Streptococcus pneumoniae:7.5 ng/mL|S. aureus:40 ng/mL

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

OP1068, OP-1068, OP 1068, Inhibitor, inhibit, Antibiotic, Bacterial, CEM101, CEM-101, CEM 101, Solithromycin

Compound Identifiers

PubChem CID

25242512