Solenopsin HCl（137038-57-4 Free base）

SKU: orb2815836

Description

Solenopsin HCl is a fire ant-derived alkaloid that acts as a dose-dependent inhibitor of PI3K signaling and angiogenesis. It is utilized in cardiovascular disease research, with applications in both in vitro and in vivo studies investigating vascular function and pathological angiogenesis.

Research Area

Signal Transduction

Key Properties

• CAS Number: 137119-46-1
• MW: 289.93
• Purity: 100.00%
• Formula: C₁₇H₃₆ClN
• SMILES: C(CCCCCCCCCC)[C@H]1N[C@H](C)CCC1.Cl
• Target: PI3K

Bioactivity

• In Vivo:
  Solenopsin HCl improves inflammation and acanthosis in psoriatic KC-Tie2 mouse models.
• In Vitro:
  Solenopsin HCl exhibits anti-angiogenic activity and down-regulates phosphoinositol-3 kinase (PI3K) in P53-deficient renal cell cancer line 786-O.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(-)-Solenopsin A HCl, Solenopsin HCl（137038-57-4 Free base）, SolenopsinHCl（137038574Freebase）

Compound Identifiers

PubChem CID

67498346