Solcitinib

SKU: orb1303990

Description

Solcitinib (GLPG-0778, GSK2586184) is a selective JAK1 inhibitor investigated for autoimmune conditions like psoriasis, ulcerative colitis, and lupus. Preclinical in vitro and in vivo studies have demonstrated its potential to modulate cytokine signaling pathways relevant to these inflammatory diseases.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1206163-45-2
• MW: 389.45
• Purity: 99.79%
• Formula: C₂₂H₂₃N₅O₂
• SMILES: CC1(C)CN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
• Target: JAK
• Solubility: DMSO:10 mg/mL (25.68 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.57 mM)

Bioactivity

• Target IC50:
  JAK1:8-9 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Solcitinib, Inhibitor, GLPG 0778, GLPG0778, GLPG-0778, GSK 2586184, GSK2586184, GSK-2586184, inhibit, Janus kinase, JAK, JAK1

Compound Identifiers

PubChem CID

44603362