Sodium Picosulfate

SKU: orb1300566

Description

Sodium Picosulfate

Key Properties

• CAS Number: 10040-45-6
• MW: 481.41
• Purity: 98.06%
• Formula: C₁₈H₁₅NO₈S₂·2Na
• SMILES: [Na+].[Na+].[O-]S(=O)(=O)Oc1ccc(cc1)C(c1ccc(OS([O-])(=O)=O)cc1)c1ccccn1
• Target: Others
• Solubility: DMSO:50 mg/mL (103.86 mM);H2O:88 mg/mL (182.8 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.15 mM);Ethanol:3 mg/mL (6.23 mM)

Bioactivity

• In Vivo:
  Sodium Picosulphate treatment for long-term has no effects on neuropeptide content o the rat colon. Over a 6-month period, daily doses (10 mg/kg/day) or twice-weekly doses (7.5 mg/kg/day) of Sodium Picosulphate do not affec the level of Vasoactive intestinal polypeptide (VIP), somatostatin, and substance P in mucosa, submucosa, or muscularis externa. Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study, 10 mg/kg Sodium Picosulphate continuously treatment does not influenc the labeling index of Brdu (LI) in the ileum and induces no statistically significant increase o the LI whe the treated groups are compared wit the control group the Proliferative pattern alon the crypts remains unchanged with sodium picosulphate treatment throughou the study. Sodium Picosulphate does not induce chronic Changes in colonic motility in rats under long-term treatment. 10 mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal.
• In Vitro:
  Sodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH Values o the rapidly growing cultured liver cells of rabbit. Comparable but less severe effects are observed in 4-day old liver cell cultures of rat, while liver cells cultured for 6 to 11 days tolerate 1600 mg mL Sodium Picosulfate. In human liver culture the number of cells is slightly lowered at 800 and 1600 mg mL an the number of nuclei in division is decreased dependent on dose.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Evacuol, Laxoberal, inhibit, Inhibitor, Picolax, Sodium Picosulfate, Sodium Picosulphate

Compound Identifiers

PubChem CID

68654