Sodium metatungstate

SKU: orb1309223

Description

Sodium metatungstate is a selective inhibitor of ecto-NTPDases, with Ki values of 2.58 µM (NTPDase1), 28.8 µM (NTPDase2), and 3.26 µM (NTPDase3). This compound is a valuable research tool for studying purinergic signaling in both cellular and animal models of thrombosis, inflammation, and cancer.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 12141-67-2
• MW: 2985.99
• Purity: 80.00% (May vary between batches)
• Formula: H₂Na₆O₄₀W₁₂
• SMILES: O=[W+4]1234[O-2][W+4]567([O-2][W+4]89%10([O-2][W+4]%11%12([O-2]1)([O-2][W+4]%13([O-2]8)([O-2][W+4]%14%15%16([O-2][W+4]%17([O-2]2)([O-2]%11)([O-2][W+4]%18([O-2][W+4]([O-2]3)([O-2]5)([O-2][W+4]%19%20([O-2][W+4]%21([O-2]6)([O-2]9)([O-2][W+4]([O-2]%13)([O-2]%14)([O-2]%19)([OH-]%21%20)=O)=O)([O-2]%18)=O)([O-2]47)=O)([O-2]%15)([OH-]%17%16)=O)=O)=O)([O-2]%12%10)=O)=O)=O)=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
• Target: P2X Receptor,P2Y Receptor,Interleukin,Pyroptosis,Phosphatase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (0.67 mM);DMSO:250 mg/mL (83.72 mM);H2O:48 mg/mL (16.08 mM)

Bioactivity

• Target IC50:
  NTPDase1:2.58 μM (ki)|NTPDase3:3.26 μM (ki)|NTPDase2:28.8 μM (ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, POM1, POM-1, POM 1, Phosphatase, Sodium metatungstate, Sodium polyoxotungstate

Quick Database Links

Gene Symbol

P2X Receptor,P2Y Receptor,Interleukin,Pyroptosis,Phosphatase