Sodium etidronate

SKU: orb1224097

Description

A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover. (In Vitro):Etidronic acid (Etidronate) (10 mM, 24 h) disodium shows cytotoxicity, causes a decrease in the S-phase population and an increase in the G2/M population, induces p53 mutation in MCF-7 cells.Etidronic acid (100 nM, 24 h) disodium induces osteoclast apoptosis, which displays characteristics of apoptosis, including chromatin condensation and changed cellular and nuclear morphology, detected by fluorescence microscopy.

Key Properties

• CAS Number: 7414-83-7
• MW: 249.99
• Purity: >98% (HPLC)
• Formula: C₂H₆Na₂O₇P₂
• SMILES: CC(O)(P(O)(O)=O)P(O)(O)=O
• Target: Tyrosinase
• Solubility: Water: 11.5 mg/mL

Bioactivity

• In Vitro:
  Etidronic acid (Etidronate) (10 mM, 24 h) disodium shows cytotoxicity, causes a decrease in the S-phase population and an increase in the G2/M population, induces p53 mutation in MCF-7 cells. Etidronic acid (100 nM, 24 h) disodium induces osteoclast apoptosis, which displays characteristics of apoptosis, including chromatin condensation and changed cellular and nuclear morphology, detected by fluorescence microscopy.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Etidronic Acid | Didronel | HEDP | Hydroxyethylidene Diphosphonic Acid

Quick Database Links

Gene Symbol

Tyrosinase