Sodium butanoate

SKU: orb1308751

Description

Sodium butanoate is the sodium salt of butyric acid, a short-chain fatty acid that acts as a competitive inhibitor of class I and II histone deacetylases (HDACs) by binding to the zinc site. This HDAC inhibitory activity underpins its research applications in studying epigenetics, cellular differentiation, and its potential antitumor effects in both in vitro and in vivo models.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 156-54-7
• MW: 110.09
• Purity: 98.02% (May vary between batches)
• Formula: C₄H₇NaO₂
• SMILES: [Na+].CCCC(=O)[O-]
• Target: HDAC,Histamine Receptor,Endogenous Metabolite,Apoptosis,Autophagy
• Solubility: H2O:250 mg/mL (2270.87 mM);DMSO:1.11 mg/mL (10.08 mM)

Bioactivity

• Target IC50:
  HDAC1:0.3 mM|MDA-MB-231 cells proliferation:5.06 mM|MCF-7 cells proliferation:5.23 mM|HDAC7:0.3 mM|HDAC2:0.4 mM|T98G cells proliferation:22.7 mM|LN-405 cells proliferation:26 mM
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• In Vivo:
  Sodium butyrate exhibits anti-inflammatory and anticancer effects in the colonic mucosa, reducing oxidative stress and thus inhibiting the growth of colon cancer cells. It also induces apoptosis in the RG/C2 and AA/Cl adenoma cell lines.
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• In Vitro:
  Sodium butyrate enhances the acetylation of histones and specific protein-1 while concurrently inhibiting the neurotoxicity induced by 3-nitropropionic acid. In the R6/2 transgenic mouse model of Huntington's disease, sodium butyrate effectively delays the onset of symptoms and prolongs the survival period.
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• Cell Research:
  Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 μL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 μL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 μL dimethylsulfoxide, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sodium Butanoate, Sodium butanoate, Sodium Butyrate, Butanoic acid sodium, Butanoic acid sodium salt, Histamine Receptor, HistamineReceptor, H1 receptor

Compound Identifiers

PubChem CID

5222465