Sodium aurothiomalate

SKU: orb1219018

Description

Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate sodium is a potent thioredoxin reductase (TrxR) inhibitor. Aurothiomalate sodium exhibits potent anti-tumor activity.

Key Properties

• CAS Number: 12244-57-4
• MW: 390.07
• Purity: >98% (HPLC)
• Formula: C₄H₃AuNa₂O₄S
• SMILES: OC(CC(S)C(O)=O)=O.[x].[Na].[Au]
• Target: PKC
• Solubility: DMSO:Soluble

Bioactivity

• In Vivo:
  Animal model: 4-6-week-old female nude mice with A427 or H460 cells. Dosage: 2, 6, 20 or 60 mg/kg. Administration: Intramuscular injections; daily; 40 days. Result: Exhibited statistically significant inhibition of tumor growth at all concentrations tested in A427 cell tumors because A427 cells are highly responsive.
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• In Vitro:
  Western blot analysis. Cell line: Bovine arterial endothelial cells (BAEC). Concentration: 25 uM. Incubation time: 6 hours. Result: Suppressed TNFa-induced NF-kB-dependent gene expression in a dose-dependent manner.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

gold sodium thiomalate | Aurothiomalate sodium | Miochrysin | Myochrysine | Myocrisin | Myocrisine

Quick Database Links

Gene Symbol

PKC