Sodium 4-phenylbutyrate

SKU: orb1308290

Description

Sodium 4-phenylbutyrate

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1716-12-7
• MW: 186.18
• Purity: 99.94%
• Formula: C₁₀H₁₁NaO₂
• SMILES: [Na+].[O-]C(=O)CCCc1ccccc1
• Target: Autophagy,HDAC,Apoptosis
• Solubility: DMSO:33.33 mg/mL (179.02 mM);H2O:33.33 mg/mL (179.02 mM)

Bioactivity

• In Vivo:
  In prostate cancer cells, Phenylbutyrate induces apoptosis by diminishing the expression levels of the cell apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker Caveolin-1, and the angiogenesis promoter Vascular Endothelial Growth Factor, thereby weakening their activity.
• In Vitro:
  In G93A transgenic ALS mice, Phenylbutyrate improves clinical symptoms and increases survival. It induces the expression of NF-κB p50 in G93A mice, while reducing the expression of cytochrome c and caspases. Additionally, in transgenic mouse models of Huntington's disease (HD), Phenylbutyrate elevates brain protein acetylation levels and reduces histone methylation levels.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, HDAC, Histone deacetylases, Inhibitor, Benzenebutyric acid, Buphenyl, Autophagy, Apoptosis, 4-Phenylbutyric acid, 4-PBA, Sodium Phenylbutyrate, Sodium 4 phenylbutyrate, Sodium 4phenylbutyrate, Sodium 4-phenylbutyrate, Tributyrate, TriButyrate

Compound Identifiers

PubChem CID

5258