Phenylbutyrate Na

SKU: orb1308290

Description

Sodium 4-phenylbutyrate

Research Area

Cell Biology, Epigenetics & Chromatin, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1716-12-7
• MW: 186.2
• Purity: >98%
• Formula: C₁₀H₁₁O₂ • Na
• SMILES: [Na+].[O-]C(=O)CCCc1ccccc1
• Target: Protein deacetylase
• Solubility: Soluble in DMSO (up to 4 mg/ml) or in Water (up to 25 mg/ml).

Bioactivity

• In Vivo:
  In prostate cancer cells, Phenylbutyrate induces apoptosis by diminishing the expression levels of the cell apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker Caveolin-1, and the angiogenesis promoter Vascular Endothelial Growth Factor, thereby weakening their activity.
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• In Vitro:
  In G93A transgenic ALS mice, Phenylbutyrate improves clinical symptoms and increases survival. It induces the expression of NF-κB p50 in G93A mice, while reducing the expression of cytochrome c and caspases. Additionally, in transgenic mouse models of Huntington's disease (HD), Phenylbutyrate elevates brain protein acetylation levels and reduces histone methylation levels.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4-PB; PBNa

Compound Identifiers

PubChem CID

5258