Sodium 4-aminosalicylate dihydrate

SKU: orb1311014

Description

Sodium 4-aminosalicylate dihydrate is a bacteriostatic antitubercular agent that inhibits Mycobacterium tuberculosis growth by disrupting folate synthesis. This compound is used in both in vitro susceptibility testing and in vivo research models to study tuberculosis pathogenesis and treatment mechanisms.

Research Area

Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 6018-19-5
• MW: 211.15
• Purity: 99.78% (May vary between batches)
• Formula: C₇H₆NNaO₃·2H₂O
• SMILES: O.[Na+].Nc1cc(O)c(cc1)C(=O)[O-].O
• Target: Free radical scavengers,Antibiotic,NF-κB,Antibacterial
• Solubility: DMSO:55 mg/mL (260.48 mM);H2O:198.9 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.47 mM)

Bioactivity

• In Vivo:
  4-Aminosalicylate exhibits effective DPPH radical scavenging activity and rapidly neutralizes hydroperoxyl radicals in aqueous solutions, displaying a concentration-dependent cycle similar to that of Trolox or cysteine, indicative of chain-breaking antioxidant activity. At 0.65 mM, 4-aminosalicylate attenuates the lethal effects of superoxide radicals or hydrogen peroxide on Chinese hamster ovary cells. In cultured mouse peritoneal macrophages, aminosalicylate (25 mM) stimulates phospholipase D in a time- and concentration-dependent manner, and at 5 mM, it enhances protein kinase C activation of PLD. Post-treatment with 4-aminosalicylate (20 mM) results in a 260% increase in inositol 1,4,5-trisphosphate levels in macrophages. Furthermore, in isolated colonic mucosal cells, 4-aminosalicylate (0.1 mM) dose-dependently reduces the synthesis of LTB4, thereby decreasing the LTB4/PGE2 ratio.
• In Vitro:
  Following local perfusion with 7.5 mg/mL of 4-aminosalicylate, N-acetyl-5-aminosalicylic acid was detected in the intestines of anesthetized rats.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sodium 4 aminosalicylate dihydrate, Sodium 4-aminosalicylate, Sodium 4-Aminosalicylate, Sodium 4aminosalicylate dihydrate, Sodium 4-aminosalicylate Dihydrate, Sodium 4-aminosalicylate dihydrate, NFkB, NF-kB, NFκB, NF-κB, inhibit, Inhibitor, Free radical scavengers, Freeradicalscavengers, Antibiotic, Bacterial, 4-Amino-salicylic acid sodium, 4-Amino-salicylic acid sodium salt, 4-Aminosalicylic acid sodium salt dihydrate

Compound Identifiers

PubChem CID

16211148