SNIPER(ER)-87

SKU: orb1987733

Description

SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERα protein with an IC50 value of 0.097 μM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERα, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERα induced by SNIPER(ER)-87.

Key Properties

• CAS Number: 2222354-91-6
• MW: 1044.32
• Formula: C₅₉H₇₃N₅O₁₀S
• SMILES: [H][C@]1(CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1)c1nc(cs1)C(=O)c1cccc(OCCOCCOCCOCC(=O)N(C)CCOc2ccc(cc2)C(=C(CC)c2ccccc2)c2ccc(O)cc2)c1 |w:58.61|
• Target: Estrogen Receptor/ERR,SNIPERs,Others

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Estrogen Receptor/ERR,SNIPERs,Others