SNIPER(ABL)-049

SKU: orb1987737

Description

SNIPER(ABL)-049 is a heterobifunctional degrader that conjugates Imatinib and Bestatin to target BCR-ABL. It effectively induces the degradation of BCR-ABL protein with a DC50 of 100 μM, providing a useful chemical tool for probing degradation pathways in chronic myeloid leukemia research, both in vitro and in vivo.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 959.14
• Formula: C₅₂H₆₆N₁₀O₈
• SMILES: CC1=CC=C(NC(C2=CC=C(CN3CCN(C(COCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC4=CC=CC=C4)N)=O)=O)=O)CC3)C=C2)=O)C=C1NC5=NC=CC(C6=CC=CN=C6)=N5
• Target: Bcr-Abl,Others,SNIPERs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138377557