SNIPER(ABL)-047

SKU: orb1987738

Description

SNIPER(ABL)-047 is a heterobifunctional degrader that conjugates an ABL kinase inhibitor to an IAP ligand, inducing proteasomal degradation of BCR-ABL. It demonstrates potent activity in cellular models with a DC50 of 2 µM, providing a valuable chemical tool for targeted protein degradation research in oncology.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 1274.5
• Formula: C₆₇H₈₂F₃N₁₁O₉S
• SMILES: CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(C4=NC5=C(N=C(NC(COCCOCCOCCNC([C@H](C(C6=CC=CC=C6)C7=CC=CC=C7)NC([C@H]8N(C([C@@H](NC([C@H](C)NC)=O)C9CCCCC9)=O)CCC8)=O)=O)=O)S5)C=C4)=CC=C3)=O)C=C2)CC1
• Target: Others,SNIPERs,Bcr-Abl

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138377568