SNIPER(ABL)-044

SKU: orb1987739

Description

SNIPER(ABL)-044 is a heterobifunctional degrader that conjugates the ABL inhibitor HG-7-85-01 to the IAP ligand Bestatin. It induces the degradation of BCR-ABL with a DC50 of 10 μM, providing a useful chemical tool for targeted protein degradation research in chronic myeloid leukemia models, both in vitro and in vivo.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 1020.17
• Formula: C₅₁H₆₄F₃N₉O₈S
• SMILES: CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(C4=NC5=C(N=C(NC(COCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC6=CC=CC=C6)N)=O)=O)=O)S5)C=C4)=CC=C3)=O)C=C2)CC1
• Target: Bcr-Abl,Others,SNIPERs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138377567