SNIPER(ABL)-039

SKU: orb1987740

Description

SNIPER(ABL)-039 is a heterobifunctional degrader that conjugates Dasatinib to an IAP ligand, inducing BCR-ABL protein degradation with a DC50 of 10 nM. It demonstrates potent activity against ABL and IAP family proteins, making it a valuable chemical probe for targeted protein degradation research in oncology, applicable in both cellular and in vivo studies.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2222354-29-0
• MW: 1114.77
• Formula: C₅₄H₆₈ClN₁₁O₉S₂
• SMILES: C([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@@](CCC2)(C3=NC(C(=O)C4=CC(OCCOCCOCCOCC(=O)N5CCN(CC5)C=6C=C(NC=7SC(C(NC8=C(C)C=CC=C8Cl)=O)=CN7)N=C(C)N6)=CC=C4)=CS3)[H]
• Target: Bcr-Abl,SNIPERs,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138377572