SNIPER(ABL)-024

SKU: orb1987742

Description

SNIPER(ABL)-024 is a heterobifunctional degrader that conjugates the ABL inhibitor GNF5 to an IAP ligand, inducing the degradation of BCR-ABL with a DC50 of 5 µM. This PROTAC-like molecule serves as a valuable chemical tool for targeted protein degradation research in chronic myeloid leukemia models, both in cellular and biochemical studies.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2222355-77-1
• MW: 1031.15
• Formula: C₅₂H₆₁F₃N₈O₉S
• SMILES: C([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@@](CCC2)(C3=NC(C(=O)C4=CC(OCCOCCOCCOCCNC(=O)C5=CC(=CC=C5)C=6C=C(NC7=CC=C(OC(F)(F)F)C=C7)N=CN6)=CC=C4)=CS3)[H]
• Target: Bcr-Abl,Others,SNIPERs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138377566